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grp

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Official Full Name
gastrin-releasing peptide
Background
Bombesin is a 14 amino acid peptide originally isolated from the skin of a frog. It has two known homologues in mammals called neuromedin B and gastrin releasing peptide. It works on the gastrointestinal tract neuroendocrine hormone and it stimulates gastrin release from G cells. It activates three different G-protein coupled receptors known as BBR1 2 & 3. It also activates these receptors in the brain. Together with cholecystokinin it is the second major source of negative feedback signals that stop eating behaviour. There are three different isoforms.
Synonyms
GRP; gastrin-releasing peptide; BN; GRP-10; proGRP; preproGRP; bombesin; neuromedin C; pre-progastrin releasing peptide; OTTHUMP00000163646; OTTHUMP00000235893; OTTHUMP00000235894; OTTHUMP00000235895; proventricular peptide; si:ch211-233a1.7; gastrin-releasing peptide-like

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