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grin2a

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Official Full Name
glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Background
The NMDA receptor (NMDAR), a glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function. The NMDAR is a specific type of ionotropic glutamate receptor. NMDA (N-methyl D-aspartate) is the name of a selective agonist that binds to NMDA receptors but not to other glutamate receptors. Activation of NMDA receptors results in the opening of an ion channel that is nonselective to cations. A unique property of the NMDA receptor is its voltage-dependent activation, a result of ion channel block by extracellular Mg2+ ions. This allows the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell to be voltage-dependent. Calcium flux through NMDARs is thought to play a critical role in synaptic plasticity, a cellular mechanism for learning and memory. The NMDA receptor is distinct in two ways: First, it is both ligand-gated and voltage-dependent; second, it requires co-activation by two ligands - glutamate and glycine (Rang et al (July 2010). Pharmacology. pp. 466.).
Synonyms
Grin2a; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDAR2A; NR2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; OTTHUMP0000016013; OTTHUMP00000174531; glutamate [NMDA] receptor subunit epsilon-1; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA receptor subtype 2A; glutamate receptor, ionotropic, NMDA2A (epsilon1); GluN2A; GluRepsilon1; OTTMUSP00000017426; EPND

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