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Official Full Name
glutamate receptor, ionotropic, delta 2
Background
Human glutamate receptor delta-2 (GRID2) is a relatively new member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain.GRID2 is a predicted 1,007 amino acid protein that shares 97% identity with the mouse homolog which is expressed selectively in cerebellar Purkinje cells.A point mutation in mouse GRID2, associated with the phenotype named lurcher, in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis.This strongly suggests a role for GRID2 in neuronal apoptotic death.
Synonyms
GRID2; glutamate receptor, ionotropic, delta 2; glutamate receptor delta-2 subunit; GluR delta 2; GLUR D2; GLURD 2; GLURD2; Glutamate receptor delta 2 subunit; Glutamate receptor ionotropic delta 2; GRID 2; MGC117022; MGC117023; MGC117024; GluR-delta-2; OTTHUMP00000161600; OTTHUMP00000219270; gluR delta-2 subunit; GluD2; si:rp71-1l7.1; glutamate receptor ionotropic, delta-2

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