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Official Full Name
glutaredoxin (thioltransferase)
Background
This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimers disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]
Synonyms
GLRX; glutaredoxin (thioltransferase); GRX; GRX1; glutaredoxin-1; TTase-1; thioltransferase-1; FLJ43648; MGC117407; GRX, GRX1; wu:fc38f02; zgc:103707; fc38f02

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