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glis3

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Official Full Name
GLIS family zinc finger 3
Background
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined.
Synonyms
GLIS3; GLIS family zinc finger 3; zinc finger protein 515 , ZNF515; zinc finger protein GLIS3; MGC33662; FLJ38999; FLJ90578; GLI similar 3; GLI SIMILAR PROTEIN 3; Zinc finger protein 515; ZNF515; OK/KNS-cl.4; GLI-similar 3; wu:fa55a05; zgc:158249

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