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fzd6

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Official Full Name
frizzled class receptor 6
Background
This gene represents a member of the frizzled gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]
Synonyms
FZD6; frizzled class receptor 6; FZ6; FZ-6; HFZ6; NDNC10; frizzled-6; frizzled homolog 6; frizzled family receptor 6; seven transmembrane helix receptor; frizzled 6, seven transmembrane spanning receptor; FZ6, FZ-6, HFZ6, NDNC10; involved in Wnt signaling, encoding a Wnt receptor; zgc:65879; zgc:77440

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