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frmpd2

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Official Full Name
FERM and PDZ domain containing 2
Background
This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants.
Synonyms
FRMPD2; FERM and PDZ domain containing 2; PDZ domain containing 5C , PDZD5C, PDZK5C; FERM and PDZ domain-containing protein 2; MGC35285; FERM and PDZ domain containing protein 2; PDZ domain containing protein 4; PDZ domain containing protein 5C; PDZD5C; PDZK4; PDZK5C; PDZ domain containing 5C; PDZ domain-containing protein 4; PDZ domain-containing protein 5C; MGC87776; MGC87777; MGC90186; MGC178184; MGC178187

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