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foxn1

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Official Full Name
forkhead box N1
Background
Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5 UTR of this gene has been observed. [provided by RefSeq, Jul 2008]
Synonyms
FOXN1; forkhead box N1; WHN; RONU; FKHL20; forkhead box protein N1; Rowett nude; winged helix nude; winged-helix nude; winged-helix transcription factor nude; nude; whnb

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