The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three;pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin;which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin;regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several;cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and;thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.
FGG; fibrinogen gamma chain; fibrinogen, gamma polypeptide; fibrinogen; fibrinogen, gamma chain; gamma chain; gamma polypeptide; fb60h05; fb62e01; zgc:56023; wu:fb60h05; wu:fb62e01