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fbxl5

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Official Full Name
F-box and leucine-rich repeat protein 5
Background
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]
Synonyms
FBXL5; F-box and leucine-rich repeat protein 5; FBL4; FBL5; FLR1; F-box/LRR-repeat protein 5; F-box protein FBL5; p45SKP2-like protein; F-box protein FBL4/FBL5; wu:fb52d06

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