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erbb2ip

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Official Full Name
erbb2 interacting protein
Background
This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.
Synonyms
ERBB2IP; erbb2 interacting protein; protein LAP2; densin 180 like protein; ERBIN; LAP2; densin-180-like protein; ERBB2-interacting protein; LAP2, ERBIN; zgc:152984

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