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eme1

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Official Full Name
essential meiotic structure-specific endonuclease 1
Background
This gene encodes a protein that complexes with methyl methanesulfonate-sensitive UV-sensitive 81 protein to form an endonuclease complex. The encoded protein interacts with specifc DNA structures including nicked Holliday junctions, 3-flap structures and aberrant replication fork structures. This protein may be involved in repairing DNA damage and in maintaining genomic stability. Alternative splicing results in multiple transcript variants.
Synonyms
EME1; essential meiotic endonuclease 1 homolog 1 (S. pombe); crossover junction endonuclease EME1; FLJ31364; MMS4L; SLX2 structure specific endonuclease subunit homolog A (S. cerevisiae); SLX2A; 6820428D13; EC 3.1.22.-; Eme1 essential meiotic endonuclease 1 homolog 1 (S. pombe); EME1, S. pombe, homolog of, 1; essential meiotic endonuclease 1 homolog 1 (S pombe); Essential Meiotic Endonuclease 1 Homolog 1; essential meiotic endonuclease 1 homolog 2; Essential meiotic endonuclease 1, S. pombe, homolog of, 1; hMMS4; homolog of yeast EME1 endonuclease; MGC106543; MMS4; MMS4 homolog; OTTHUMP00000221188; OTTHUMP00000221189; OTTHUMP00000221193; SLX2 structure-specific endonuclease subunit homolog A

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