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eda2r

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Official Full Name
ectodysplasin A2 receptor
Background
EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that are encoded by the anhidrotic ectodermal dysplasia (EDA) gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. The protein encoded by this gene specifically binds to EDA-A2 isoform. This protein is a type III transmembrane protein of the TNFR (tumor necrosis factor receptor) superfamily, and contains 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. Alternatively spliced transcript variants have been found for this gene.
Synonyms
EDA2R; ectodysplasin A2 receptor; XEDAR; EDAA2R; EDA-A2R; TNFRSF27; Tumor necrosis factor receptor superfamily member 27; X-linked ectodysplasin-A2 receptor; EDA-A2 receptor; UNQ2448/PRO5727/PRO34080; OTTHUMP00000023448; tumor necrosis factor receptor superfamily member XEDAR; X-linked EDA-A2 Receptor; EDA A2R; RGD1564025, Eda2r; X-linked ectodysplasin receptor

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