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dppa2

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Official Full Name
developmental pluripotency associated 2
Background
DPPA-2 (developmental pluripotency associated-2) is a novel Oct-4-related protein that is localized to the nucleus of mouse fetal germ cells. DPPA-2 has binding sites for both POU and Sox-2 protein domains and is expressed primarily in the developing germ line following gastrulation. These associations suggest that this protein participates in a very strong supportive role in maintaining cell pluripotentiality. In addition to its role as a pluripotency marker, more recent research using cancer cells suggests that DPPA-2 may also act as an embryo-cancer antigen—pointing to the presence of abnormal cell growth and the formation of cancerous cells.
Synonyms
DPPA2; developmental pluripotency associated 2; developmental pluripotency-associated protein 2; developmental pluripotency-associated 2; embryonic stem cell-associated transcript 15-2 protein; pluripotent embryonic stem cell-related gene 1 protein; C80932; D19Mgi18; ECAT15-2; 2410088E07Rik; cancer/testis antigen 100; CT100; PESCRG1; embryonic stem cell (ESC) associated transcript 15-2

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