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dph1

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Official Full Name
diphthamide biosynthesis 1
Background
Diphthamide is a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM;130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation;and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. DPH1 is 1 of several enzymes involved in;synthesis of diphthamide in EEF2 (Liu et al., 2004 (PubMed 15485916)).
Synonyms
DPH1; DPH1 homolog (S. cerevisiae); diptheria toxin resistance protein required for diphthamide biosynthesis like 1 (S. cerevisiae) , DPH like 1 (S. cerevisiae) , DPH2L, DPH2L1; diphthamide biosynthesis protein 1; ovarian tumor suppressor candidate 1; OVCA1; DPH-like 1; DPH2-like 1; ovarian cancer-associated gene 1 protein; candidate tumor suppressor in ovarian cancer 1; diphthamide biosynthesis protein 2 homolog-like 1; diptheria toxin resistance protein required for diphthamide biosynthesis-like 1; diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1; DPH2L; DPH2L1; FLJ33211; diphthamide biosynthesis 1; DPH1 homolog; zgc:110702

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