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dmtf1

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Official Full Name
cyclin D binding myb-like transcription factor 1
Background
This gene encodes a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
Synonyms
DMTF1; cyclin D binding myb-like transcription factor 1; cyclin-D-binding Myb-like transcription factor 1; cyclin D binding Myb like protein; DMP1; DMTF; hDMP1; hDMTF1; cyclin D-binding Myb-like protein; cyclin-D-interacting Myb-like protein 1; FLJ25188; FLJ41265; FLJ76054; DMP1, DMTF, hDMP1; zgc:92448

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