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dmap1

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Official Full Name
DNA methyltransferase 1 associated protein 1
Background
This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Synonyms
DMAP1; DNA methyltransferase 1 associated protein 1; EAF2; SWC4; MEAF2; DNMAP1; DNMTAP1; DNA methyltransferase 1-associated protein 1; DNMT1 associated protein 1; DNMT1-associated protein 1; zgc:55593

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