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dlg5

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Official Full Name
discs, large homolog 5 (Drosophila)
Background
This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined.
Synonyms
DLG5; discs, large homolog 5 (Drosophila); discs, large (Drosophila) homolog 5; disks large homolog 5; KIAA0583; P dlg; Discs large homolog 5 (Drosophila); Discs large homolog 5; Discs large protein LP DLG; Discs large protein P dlg; Discs large protein P-dlg; DLG 5; DLG5_HUMAN; Large type of P DLG; LP DLG; P DLG5; PDLG; Placenta and prostate DLG; OTTHUMP00000019917; OTTHUMP00000019918; large type of P-DLG; discs large protein LP-DLG; LP-DLG; P-DLG5

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