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dad1

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Official Full Name
defender against cell death 1
Background
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes.
Synonyms
OST2; DAD1; Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1; Oligosaccharyl transferase subunit DAD1; EC=2.4.1.119; Defender against cell death 1; AD-1; OTTHUMP00000164488; OTTHUMP00000239715; OTTHUMP00000239717; DAD-1; dolichyl-diphosphooligosaccharide--protein glycosyltransfe-rase subunit DAD1; EC 2.4.1.119; oligosaccharyltransferase 2 homolog; oligosaccharyltransferase 2 homolog (S. cerevisiae); apoptotic suppressor; defender against death protein 1; defender against cell death 1 protein; si:ch211-9d9.5

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