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dact1

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Official Full Name
dishevelled-binding antagonist of beta-catenin 1
Background
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
Synonyms
DACT1; dishevelled-binding antagonist of beta-catenin 1; DPR1; FRODO; HDPR1; DAPPER; THYEX3; DAPPER1; dapper homolog 1; dapper antagonist of catenin 1; heptacellular carcinoma novel gene 3; dapper, antagonist of beta-catenin, homolog 1; hepatocellular carcinoma novel gene 3 protein; dapper 1; frd1; frodo1; frodo 1; dishevelled-interacting protein; dapper homolog 1, antagonist of beta-catenin

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