Cytokine-induced neutrophil chemo attractant 1(CINC-1) was originally purified from media conditioned by IL-1βstimulated rat kidney epithelioid cells (NRK-52E). Amino acid sequence that encodes for rat CINC-1 was identified in 1989 by Watanabe's group at Toyama Medical and Pharmaceutical University. CINC-1 is a member of the alpha (CXC) subfamily of chemokines. Three additional rat CXC chemokines (CINC-2α, CINC-2β, CINC-3/MIP-2) have been identified. The protein sequence of CINC-1 is 63 - 67% identical to that of CINC-2α, CINC-2β, CINC-3/MIP-2. In addition, GROα, GROβ and GROγ is sharing 68%, 71% and 69%, identity with CINC-1. This has been suggested that CINCs are the rat counterpart of human GROs.
Cxcl3; Cinc2; Cinc-2; Gm1960; chemokine (C-X-C motif) ligand 3; GRO-gamma; SCYB3; GRO-gamma(1-73); GRO3; MIP2-beta; CINC-2b; MIP2B; GROg; MIP-2b; C-X-C motif chemokine 3; GRO3 oncogene; melanoma growth stimulatory activity gamma; Growth-regulated protein gamma; MGSA gamma2; Macrophage inflammatory protein 2-beta; MIP2-alpha/beta; macrophage inflammatory protein 2-alpha/beta; cytokine-induced neutrophil chemoattractant 2; cytokine-induced neutrophil chemoattractant-2; GRO3, GRO3 oncogene; CINC 2b; MIP 2b; MGSA gamma