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ctnna1

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Official Full Name
catenin (cadherin-associated protein), alpha 1, 102kDa
Background
The distinct peripheral cytosolic proteins, alpha, beta and gamma-catenin (102, 94 and 86 kDa) found in many tissues bind to the conserved cytoplasmic tail domain of the cell-adhesion cadherins. Catenins link E-cadherin to other integral membrane or cytoplasmic proteins and are modulated by Wnt-1 proto-oncogene. They are good candidates for mediating transduction of cell-cell contact positional signals to the cell interior. Absence of alpha-catenin is found in certain tumor cell lines and reduced levels in certain human carcinomas. Beta-catenin binds directly to the cytoplasmic tail of E-cadherin. It binds to the N-terminus of alpha-catenin and interacts with the protein product of the tumor suppressor gene APC. This interaction involves a 15-aa repeat in the APC. Beta-catenin cell levels seem to be controlled by APC. The central core region of beta-catenin is involved in mediation of cadherin-catenin complex interaction with EGFR.
Synonyms
alpha catenin; alpha E catenin; alphaE catenin; Cadherin associated protein 102kDa; Cadherin associated protein; CAP 102; CAP102; Catenin (cadherin associated protein) alpha 1 102kDa; Catenin (cadherin associated protein), alpha 1, 102kDa; Catenin alpha 1; CTNNA 1; CTNNA1; FLJ36832; FLJ52416; NY REN 13 antigen; OTHUMP00000224141; OTTHUMP00000224147; Renal carcinoma antigen NY REN 13 alpha catenin; Renal carcinoma antigen NY REN 13; alpha-Cat; a-cat; alpha-ctn; alphacat; CG17947; CT39986; Dalpha-cat; Dalpha-catenin; DalphaC; Dalphacat; Dmcatp; Dmel\CG17947; CG17947-PA; D-alpha-catenin; Dalpha-cadherin; DalphaCatenin; a-catenin; alpha-Cat-PA; alpha-Catenin; alphaCatenin; CG17947 gene product from transcript CG17947-RA; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin (cadherin associated protein), alpha 1 (102kD); catenin alpha-1; alphaE-catenin; alpha E-catenin; alpha-E-catenin; renal carcinoma antigen NY-REN-13; cadherin-associated protein,102kDa; catenin (cadherin-associated protein), alpha 1; ctnna; [a]E-catenin

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