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corin

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Official Full Name
corin, serine peptidase
Background
Corin, also known as Atrial Natriuretic Peptide-converting enzyme, is a 1042 amino acid single-pass type II membrane protein that is found on the cell membrane. It is highly expressed in the heart and heart myocytes. Corin is a serine-type endopeptidase that is involved in atrial natriuretic peptide hormone processing. It converts, through proteolytic cleavage, the non-functional propeptide NPPA/ANP into the active hormone which promotes natriuresis, diuresis, and vasodilatation. Corin may also process pro-NPPB the B-type natriuretic peptide. Enzyme regulation is inhibited in a dose-dependent manner by non-specific trypsin-like serine protease inhibitors including benzamidine. Corin is N-glycosylated, which is required for processing and activation. It is consists of a disulfide bond that links the N- terminal propeptide and the activated Corin protease fragment. Corin is activated through proteolytic processing by a trypsin-like protease: cleaved into an N-terminal propeptide and an activated Corin protease fragment. It is initially named Corin due to its abundant expression in the heart.
Synonyms
ATC2; CRN; Lrp4; PEE5; TMPRSS10; atrial natriuretic peptide-converting enzyme; heart-specific serine proteinase ATC2; pro-ANP-convertase; pro-ANP-converting enzyme; transmembrane protease serine 10; CORIN; corin, serine peptidase; corin, serine protease; PRSC; heart specific serine proteinase; atrial natriuteric peptide-converting enzyme; MGC119742

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