Creative biogene
SHARE THIS
facebook twitterlinkedingoogle plusStumbleUpon blog


  Order Info:   order info
Products
CBpromise

24x7 CUSTOMER SERVICE

CONTACT US TO ORDER

;

clec4a

Bookmark and Share
Official Full Name
C-type lectin domain family 4, member A
Background
A member of the calcium-dependent (C-type) lectin receptor (CLR) family, DCIR (for dendritic cell (DC) immunoreceptor), is a type II membrane glycoprotein of 237 aa with a single carbohydrate recognition domain (CRD), closest in homology to those of the macrophage lectin and hepatic asialoglycoprotein receptors. The intracellular domain of DCIR contains a consensus immunoreceptor tyrosine-based inhibitory motif (ITIM). A mouse cDNA, encoding a homologous protein has been identified. Northern blot analysis shows that DCIR mRNA is predominantly transcribed in hematopoietic tissues. DCIR displays a typical lectin CRD and is expressed on DCs, monocytes, macrophages, B lymphocytes, and granulocytes, but not detected on NK and T cells. DCIR is strongly expressed by DCs derived from blood monocytes cultured with GM-CSF and IL-4. DCIR is preferentially expressed by monocyte-related rather than Langerhans cell related DCs obtained from CD34+ progenitor cells. Finally, DCIR expression is down-regulated by signals inducing DC maturation such as CD40 ligand, LPS, or TNF- . Thus, DCIR is differentially expressed on DCs depending on their origin and stage of maturation/activation. DCIR represents a novel surface molecule expressed by antigen-presenting cells, and of potential importance in regulation of DC function.
Synonyms
DCIR; LLIR; DDB27; CLECSF6; HDCGC13P; C-type lectin domain family 4 member A; C-type lectin DDB27; lectin-like immunoreceptor; dendritic cell immunoreceptor; C-type lectin superfamily member 6; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6; OTTHUMP00000239071; OTTHUMP00000239070; OTTHUMP00000239052; CLEC4A; C-type lectin domain family 4, member A; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 6 , CLECSF6

CONTACT CREATIVE BIOGENE

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

Terms & Conditions | Privacy Policy | Sitemap | FAQ | © 2010-2017 Creative Biogene. All Rights Reserved.
-->