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clcn4

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Official Full Name
chloride channel, voltage-sensitive 4
Background
The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders.
Synonyms
CLCN4; chloride channel, voltage-sensitive 4; chloride channel 4; H(+)/Cl(-) exchange transporter 4; ClC 4; CLC4; chloride channel protein 4; chloride transporter ClC-4; ClC-4; ClC-4A; MGC163150; zgc:153764

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