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chrdl2

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Official Full Name
chordin-like 2
Background
CHRDL2 is a novel chordin like protein that can act as a BMP antagonist. A member of the chordin family of proteins, it contains a signal peptide and three CR (cysteine-rich repeat) domains. When expressed as a recombinant protein it is secreted and binds to activin A, but not to BMP-2, -4, -6. Differential expression has been detected in developing chondrocytes, myoblasts, osteoblasts, and osteoarthritic joints. Complex alternative splicing of CHRDL2 potentially results in distinct isoforms that differ at their C termini, in the expression of signal peptide, and in the content of CR domains. CHRDL2 was originally characterized as a novel protein exclusively expressed in breast, lung, and colon tumors.
Synonyms
CHRDL2; chordin-like 2; BNF1; CHL2; FKSG37; DKFZp586N2124; chordin-like protein 2; BNF-1; chordin-related protein 2; breast tumor novel factor 1; OTTHUMP00000230490; OTTHUMP00000230491; OTTHUMP00000230494; chl; si:dkey-11j5.7; si:dkey-11j5.7-like

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