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chmp2b

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Official Full Name
charged multivesicular body protein 2B
Background
This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]
Synonyms
CHMP2B; charged multivesicular body protein 2B; DMT1; ALS17; VPS2B; VPS2-2; CHMP2.5; VPS2 homolog B; chromatin modifying protein 2B; vacuolar protein-sorting-associated protein 2-2; DKFZP564O123; VPS2 homolog B (S. cerevisiae); DMT1, ALS17, VPS2B, VPS2-2, CHMP2.5; chromatin-modifying protein 2b

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