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cfl1

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Official Full Name
cofilin 1 (non-muscle)
Background
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
Synonyms
CFL1; cofilin 1 (non-muscle); CFL; HEL-S-15; cofilin-1; p18; 18 kDa phosphoprotein; cofilin, non-muscle isoform; epididymis secretory protein Li 15; cb86; sb:cb86; zgc:56501; wu:fb18a04; wu:fk77b03; non-muscle cofilin 1

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