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cfhr1

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Official Full Name
complement factor H-related 1
Background
This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome.
Synonyms
CFHR1; complement factor H-related 1; CFHL1, CFHL1P, CFHR1P, complement factor H related 1 pseudogene , H factor (complement) like 1 , H factor (complement) like 2 , HFL1, HFL2; complement factor H-related protein 1; CFHL; FHR1; H36 1; H36 2; CFHL1; CFHL1P; CFHR1P; Complement factor H related 1 pseudogene; Complement factor H related protein 1 precursor; FHR 1; FHR-1; FHR1_HUMAN; H factor (complement) like 1; H factor (complement) like 2; H factor like protein 1; H factor-like protein 1; H-factor-like 1; H36; HFL1; HFL2; MGC104329; H factor (complement)-like 1; H factor (complement)-like 2; complement factor H-related 1 pseudogene; H36-1; H36-2

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