Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.
CENPH; centromere protein H; NNF1; MIND kinetochore complex component; homolog (S. cerevisiae); PMF1; CENP H; CENP-H; CENPH_HUMAN; ICEN35; Interphase centromere complex protein 35; Kinetochore protein CENP H; NNF1, MIND kinetochore complex component, homolog; OTTHUMP00000123477; OTTHUMP00000221978; OTTHUMP00000221979; kinetochore protein CENP-H; si:dkey-186m8.3