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ccnf

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Official Full Name
cyclin F
Background
This gene encodes a member of the cyclin family. Cyclins are important regulators of cell cycle transitions through their ability to bind and activate cyclin-dependent protein kinases. This member also belongs to the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it was one of the first proteins in which the F-box motif was identified.
Synonyms
CCNF; cyclin F; cyclin-F; FBX1; FBXO1; F box only protein 1; G2 mitotic specific cyclin F; OTTHUMP00000159081; F-box only protein 1; G2/mitotic-specific cyclin-F; cb443; zgc:77240

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