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casp4

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Official Full Name
caspase 4, apoptosis-related cysteine peptidase
Background
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.
Synonyms
Apoptosis related cysteine peptidase; Apoptotic cysteine protease Mih1/TX; CASP 4; CASP-4; CASP4; CASP4_HUMAN; Caspase-4 subunit 2; Caspase4; ICE(rel) II; ICE(rel)-II; ICE(rel)II; ICEREL II; ICERELII; ICH 2; Mih1/TX; Protease ICH-2; Protease TX; TX; TX protease; OTTHUMP00000231863; OTTHUMP00000231864; caspase 4, apoptosis-related cysteine protease; EC 3.4.22.57; EC 3.4.22

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