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cacnb1

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Official Full Name
calcium channel, voltage-dependent, beta 1 subunit
Background
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. Calcium channel, voltage-dependent, β1 subunit, also known as CACNB1, is a human gene. The protein encoded by this gene belongs to the calcium channel β subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the α1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.
Synonyms
CACNB1; calcium channel, voltage-dependent, beta 1 subunit; CACNLB1; voltage-dependent L-type calcium channel subunit beta-1; calcium channel, L type, beta 1 polypeptide; calcium channel voltage-dependent subunit beta 1; dihydropyridine-sensitive L-type,; dihydropyridine-sensitive L-type, calcium channel beta-1 subunit; CAB1; CCHLB1; MGC41896; zgc:91982; red; relaxed; dihydropyridine receptor b1; calcium channel beta1a subunit; dihydropyridine receptor beta 1a subunit; dihydropyr

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