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cacna1c

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Official Full Name
calcium channel, voltage-dependent, L type, alpha 1C subunit
Background
Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage-gated ion channels, ligand-gated, other gating systems, and finally those that are classified differently, having more exotic characteristics. Specifically, Cav1.2 is a cardiac L-type calcium channel and is important for excitation and contraction of the heart. It may be associated with a variant of Long QT syndrome called Timothy’s syndrome and also with Brugada syndrome. Some references suggest it is related to bipolar disease as well.
Synonyms
CACNA1C; Cav1.2 Calcium Channel; calcium channel, voltage-dependent, L type, alpha 1C subunit; TS; CACH2; CACN2; CaV1.2; CCHL1A1; CACNL1A1; MGC120730; voltage-dependent L-type calcium channel subunit alpha-1C; DHPR, alpha-1 subunit; calcium channel, cardic dihydropyridine-sensitive, alpha-1 subunit; calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle; voltage-gated L-type calcium channel Cav1.2 alpha 1 subunit, splice variant 10*; Voltage-gated calcium channel subunit alpha Cav1.2; OTTHUMP00000196730; OTTHUMP00000196731; OTTHUMP00000196732; OTTHUMP00000196733; OTTHUMP00000196734; OTTHUMP00000196735; OTTHUMP00000196736; OTTHUMP00000196737; OTTHUMP00000196738; OTTHUMP00000196739; OTTHUMP00000196740; OTTHUMP00000196741; OTTHUMP00000196742; OTTHUMP00000196743; OTTHUMP00000196744; OTTHUMP00000196745; OTTHUMP00000196746; OTTHUMP00000196747; OTTHUMP00000196748; OTTHUMP00000196749; OTTHUMP00000196750; OTTHUMP00000196751; OTTHUMP00000238277; OTTHUMP00000238278; OTTHUMP00000238279; isl; C-LTCC; ZfCav1.2; island beat; CACB

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