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bub1

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Official Full Name
BUB1 mitotic checkpoint serine/threonine kinase
Background
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Synonyms
BUB1; BUB1 mitotic checkpoint serine/threonine kinase; BUB1A; BUB1L; hBUB1; mitotic checkpoint serine/threonine-protein kinase BUB1; mitotic spindle checkpoint kinase; putative serine/threonine-protein kinase; budding uninhibited by benzimidazoles 1 homolog; BUB1 budding uninhibited by benzimidazoles 1 homolog; budding uninhibited; BUB1L, budding uninhibited by benzimidazoles 1 (yeast homolog); protein kinase Bub1

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