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baiap2

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Official Full Name
BAI1-associated protein 2
Background
The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein.;This adaptor protein links membrane bound G-proteins to cytoplasmic effector proteins. This protein functions as an;insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. It also;associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers;and cytokinesis. This protein is involved in lamellipodia and filopodia formation in motile cells and may affect;neuronal growth-cone guidance. This protein has also been identified as interacting with the;dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease.;Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms
BAIAP2; BAI1-associated protein 2; brain-specific angiogenesis inhibitor 1-associated protein 2; BAP2; IRS-58; IRSp53/58; fas ligand-associated factor 3; insulin receptor substrate p53/p58; insulin receptor substrate protein of 53 kDa; FLAF3; IRSP53; BAP2, FLAF3, IRSP53

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