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b4galt3

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Official Full Name
UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
Background
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
Synonyms
B4GALT3; UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3; beta-1,4-galactosyltransferase 3; beta4Gal T3; b4Gal T3; Beta 1,4 galactosyltransferase 3; Beta 1,4 GalTase 3; UDP Gal:beta GlcNAc beta-1,4 galactosyltransferase 3; b4Gal-T3; OTTHUMP00000032247; OTTHUMP00000032248; beta-1,4-GalTase 3; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3; beta-N-acetylglucosaminyl-glycolipid beta-1,4-galactosyltransferase 3; UDP-galactose:beta-N-acetylglucos; beta4Gal-T3; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3

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