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axl

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Official Full Name
AXL receptor tyrosine kinase
Background
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Synonyms
AXL; AXL receptor tyrosine kinase; UFO; JTK11; tyrosine-protein kinase receptor UFO; AXL oncogene; AXL transforming sequence/gene; oncogene AXL; Ark; Tyro7; AI323647

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