Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.
AXIN1; axin 1; axin-1; PPP1R49; protein phosphatase 1; regulatory subunit 49; AI316800; AXIN; AXIN1_HUMAN; Axis inhibition protein 1; Axis Inhibitor 1; hAxin; Kb; Ki; kinky; knobbly; protein phosphatase 1, regulatory subunit 49; fused, mouse, homolog of; MGC52315; AXIN1-RGS; wu:fi22e03; wu:fj14c08; wu:fk11b03; zgc:109872; mbl; masterblind