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atp6v1e1

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Official Full Name
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
Background
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain E subunit isoforms. Pseudogenes for this gene have been found in the genome.
Synonyms
ATP6V1E1; ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1; ATP6E, ATP6V1E, ATPase, H+ transporting, lysosomal (vacuolar proton pump) 31kD , ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1; V-type proton ATPase subunit E 1; ATP6E2; P31; Vma4; ATP6E; ATP6V1E; V ATPase 31 kDa subunit; Vacuolar proton pump subunit E 1; OTTHUMP00000065606; OTTHUMP00000196213; OTTHUMP00000214152; OTTHUMP00000214153; V-ATPase, subunit E; V-ATPase subunit E 1; V-ATPase 31 kDa subunit; H+-transporting ATP synthase chain E, vacuolar; H(+)-transporting two-sector ATPase, 31kDa subunit; P31, Vma4, ATP6E, ATP6E2, ATP6V1E; ATPase, H+ transporting, vacuolar, V1 subunit E

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