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atp6v1a

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Official Full Name
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
Background
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of;eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular;processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient;generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of;three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP;catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. Additional isoforms of many of;the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This;encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived;from alternative polyadenylation exist.
Synonyms
ATP6V1A; ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A; ATP6A1, ATP6V1A1, ATPase, H+ transporting, lysosomal (vacuolar proton pump), alpha polypeptide, 70kD, isoform 1 , VPP2; V-type proton ATPase catalytic subunit A; VA68; Vma1; V-ATPase subuni; V-ATPase subunit A; V-ATPase 69 kDa subunit; vacuolar proton pump subunit alpha; A2 isoform of vacuolar H+-ATPase subunit A

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