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apln

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Official Full Name
apelin
Background
This gene encodes a peptide that functions as an endogenous ligand for the G protein coupled receptor APJ. The encoded protein is synthesized as a prepropeptide that is processed into biologically active C-terminal fragments. The peptide fragments activate different tissue specific signaling pathways that regulate diverse biological functions including fluid homeostasis, cardiovascular function and insulin secretion. This protein also functions as a coreceptor for the human immunodeficiency virus 1.
Synonyms
APLN; apelin; apelin, AGTRL1 ligand; XNPEP2; AGTRL1 ligand; APEL; APEL_HUMAN; Apelin-13; APJ endogenous ligand

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