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ankhd1

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Official Full Name
ankyrin repeat and KH domain containing 1
Background
This gene encodes a protein with multiple ankyrin repeat domains and a single KH-domain. The protein is thought to function as a scaffolding protein, and it may be involved in the regulation of caspases and thereby play an antiapoptotic role in cell survival. Alternative splicing results in multiple transcript variants, one of which generates a fusion transcript (MASK-BP3) with the downstream eIF4E-binding protein 3 (EIF4EBP3) gene, resulting in a protein comprised of the ANKHD1 sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments.
Synonyms
ANKHD1; ankyrin repeat and KH domain containing 1; ankyrin repeat and KH domain-containing protein 1; FLJ10042; FLJ11979; FLJ14127; FLJ20288; KIAA1085; MASK; ANKH1_HUMAN; ANKHD 1; Ankyrin repeat and KH domain containing protein 1; HIV-1 Vpr-binding ankyrin repeat protein; HIV1 Vpr binding ankyrin repeat protein; hMASK; Multiple ankyrin repeats single KH domain; Multiple ankyrin repeats single KH domain homolog; PP2500; VBARP; OTTHUMP00000159883; OTTHUMP00000174758; OTTHUMP00000174759; OTTHUMP00000174760; multiple ankyrin repeats, single KH-domain homolog

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