The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction. Genetic variations in this gene are associated with absorptive hypercalciuria type 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
ADCY10; adenylate cyclase 10 (soluble); adenylate cyclase type 10; HCA2; Hypercalciuria; absorptive; 2; RP1 313L4.2; SAC; SACI; Sacy; soluble adenylyl cyclase; hsAC; AH-related protein; ATP pyrophosphate-lyase; 3,5-cyclic AMP synthetase; germ cell soluble; germ cell soluble adenylyl cyclase; testicular soluble adenylyl cyclase (SAC); RP1-313L4.2