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adamtsl2

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Official Full Name
ADAMTS-like 2
Background
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) and ADAMTS-like protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene lacks the protease domain, and is therefore of a member of the the ADAMTS-like protein subfamily. It is a secreted glycoprotein that binds the cell surface and extracellular matrix; it also interacts with latent transforming growth factor beta binding protein 1. Mutations in this gene have been associated with geleophysic dysplasia.
Synonyms
ADAMTSL2; ADAMTS-like 2; ADAMTS-like protein 2; KIAA0605; ADAMTS like 2; ADAMTS like protein 2; ADAMTSL 2; ADAMTSL-2; ATL2_HUMAN; FLJ45164; GPHYSD1

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