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SOCS2


Official Full Name
suppressor of cytokine signaling 2
Organism
Homo sapiens
Gene ID
8835
Background
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Synonyms
CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2

Cat.No. Product Name Price
SHH414952 shRNA set against Human SOCS2 (NM_003877.4) Inquiry
SHH414956 shRNA set against Mouse SOCS2 (NM_007706.4) Inquiry
SHH414960 shRNA set against Rat SOCS2 (NM_058208.1) Inquiry
SHL024258 shRNA set against Rat Socs2(NM_058208.1) Inquiry
SHW005052 shRNA set against Chicken SOCS2 (NM_204540) Inquiry
SHW012314 shRNA set against Danio rerio SOCS2 (NM_001114550) Inquiry
Cat.No. Product Name Price
CDCS411521 Human SOCS2 ORF Clone (BC010399) Inquiry
CDFG022025 Mouse Socs2 cDNA Clone(BC106153) Inquiry
CDFR013792 Rat Socs2 cDNA Clone(NM_058208.1) Inquiry
MiUTR3H-07384 SOCS2 miRNA 3'UTR clone Inquiry
CDCB160436 Human SOCS2 ORF clone (NM_003877.3) Inquiry
CDCB166527 Chicken SOCS2 ORF Clone (NM_204540) Inquiry
CDCB173789 Danio rerio SOCS2 ORF Clone (NM_001114550) Inquiry
CDCB185518 Rabbit SOCS2 ORF clone (XM_002711201.2) Inquiry
CDCR241942 Mouse Socs2 ORF Clone(NM_001168655.1) Inquiry
CDCR241943 Mouse Socs2 ORF Clone(NM_001168656.1) Inquiry
CDCR241945 Mouse Socs2 ORF Clone(NM_001168657.1) Inquiry
CDCR244109 Mouse Socs2 ORF Clone(NM_007706.4) Inquiry
CDCR380825 Rat Socs2 ORF Clone(NM_058208.1) Inquiry
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