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OAZ1


Official Full Name
ornithine decarboxylase antizyme 1
Organism
Homo sapiens
Gene ID
4946
Background
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
Synonyms
AZ1; AZI; OAZ

Cat.No. Product Name Price
SHH357036 shRNA set against Human OAZ1 (NM_004152.2) Inquiry
SHR029262 shRNA set against Mouse Oaz1(NM_008753.4) Inquiry
SHH357040 shRNA set against Mouse OAZ1 (NM_008753.4) Inquiry
SHR029072 shRNA set against Human OAZ1(NM_004152.2) Inquiry
SHR029076 shRNA set against Rat Oaz1(NM_139081.1) Inquiry
SHW005421 shRNA set against Chicken OAZ1 (NM_204916) Inquiry
SHW015597 shRNA set against Danio rerio OAZ1A (NM_194264) Inquiry
Cat.No. Product Name Price
CDCL141043 Mouse Oaz1 ORF clone (NM_008753.4) Inquiry
CDCS411640 Human OAZ1 ORF Clone (BC093652) Inquiry
CDFL008712 Mouse Oaz1 cDNA Clone(NM_008753.4) Inquiry
MiUTR1H-07022 OAZ1 miRNA 3'UTR clone Inquiry
MiUTR1M-07933 OAZ1 miRNA 3'UTR clone Inquiry
MiUTR1R-04352 OAZ1 miRNA 3'UTR clone Inquiry
SKO0231 OAZ1 Validated sgRNA vector Inquiry
CDCB166896 Chicken OAZ1 ORF Clone (NM_204916) Inquiry
CDCB177072 Danio rerio OAZ1A ORF Clone (NM_194264) Inquiry
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