Pages
Products

NRG3


Official Full Name
neuregulin 3
Organism
Homo sapiens
Gene ID
10718
Background
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]
Synonyms
HRG3; pro-NRG3

Cat.No. Product Name Price
SHH355056 shRNA set against Human NRG3 (NM_001010848.3) Inquiry
SHH355060 shRNA set against Mouse NRG3 (NM_008734.3) Inquiry
Cat.No. Product Name Price
CDFH012863 Human NRG3 cDNA Clone(NM_001165972.1) Inquiry
CDFH012864 Human NRG3 cDNA Clone(NM_001165973.1) Inquiry
MiUTR3H-07770 NRG3 miRNA 3'UTR clone Inquiry
MiUTR3H-07771 NRG3 miRNA 3'UTR clone Inquiry
MiUTR3H-07772 NRG3 miRNA 3'UTR clone Inquiry
CDCL139929 Human NRG3 ORF clone (NM_001165973.1) Inquiry
CDCL139931 Human NRG3 ORF clone (NM_001165972.1) Inquiry
CDCL151488 Mouse Nrg3 ORF clone (NM_001190188.1) Inquiry
CDCR243068 Mouse Nrg3 ORF Clone(NM_001190187.1) Inquiry
CDCR246031 Mouse Nrg3 ORF Clone(NM_008734.3) Inquiry
CDCR340622 Human NRG3 ORF Clone(NM_001010848.3) Inquiry
Quick Inquiry