Pages
Products

MCM4


Official Full Name
minichromosome maintenance complex component 4
Organism
Homo sapiens
Gene ID
4173
Background
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Synonyms
NKCD; CDC21; CDC54; IMD54; NKGCD; hCdc21; P1-CDC21

Cat.No. Product Name Price
SHH339311 shRNA set against Human MCM4 (NM_005914.3) Inquiry
SHH339315 shRNA set against Mouse MCM4 (NM_008565.3) Inquiry
SHH339319 shRNA set against Rat MCM4 (NM_033651.1) Inquiry
SHW015759 shRNA set against Danio rerio MCM4 (NM_198913) Inquiry
Cat.No. Product Name Price
MiUTR3H-05161 MCM4 miRNA 3'UTR clone Inquiry
MiUTR3H-05162 MCM4 miRNA 3'UTR clone Inquiry
CDCB177234 Danio rerio MCM4 ORF Clone (NM_198913) Inquiry
CDCB187981 Rabbit MCM4 ORF clone (XM_002710523.2) Inquiry
Quick Inquiry