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CTSB


Official Full Name
cathepsin B
Organism
Homo sapiens
Gene ID
1508
Background
This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer's disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Both Cathepsin B and Cathepsin L are involved in the cleavage of the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) upon its entry to the human host cell. Multiple pseudogenes of this gene have been identified. [provided by RefSeq, Sep 2020]
Synonyms
KWE; APPS; CPSB; RECEUP

Cat.No. Product Name Price
SHG206659 shRNA set against Human CTSB(NM_001908.3) Inquiry
SHG206763 shRNA set against Rat Ctsb(NM_022597.2) Inquiry
SHH271493 shRNA set against Human CTSB (NM_001908.3) Inquiry
SHH271497 shRNA set against Mouse CTSB (NM_007798.3) Inquiry
SHH271501 shRNA set against Rat CTSB (NM_022597.2) Inquiry
SHW005866 shRNA set against Chicken CTSB (NM_205371) Inquiry
Cat.No. Product Name Price
SKO1110 CTSB Validated sgRNA vector Inquiry
MiUTR1R-01259 CTSB miRNA 3'UTR clone Inquiry
MiUTR1H-02542 CTSB miRNA 3'UTR clone Inquiry
CDFR012030 Rat Ctsb cDNA Clone(NM_022597.2) Inquiry
CDCR244329 Mouse Ctsb ORF Clone(NM_007798.3) Inquiry
CDFH004487 Human CTSB cDNA Clone(NM_001908.3) Inquiry
CDFG009183 Human CTSB cDNA Clone(NM_147783.2) Inquiry
CDFG009182 Human CTSB cDNA Clone(NM_147782.2) Inquiry
CDCR318857 Human CTSB ORF Clone(NM_147783.2) Inquiry
CDFG009181 Human CTSB cDNA Clone(NM_147781.2) Inquiry
MiUTR4H-TG11016 CTSB miRNA 3'UTR clone Inquiry
CDFG009180 Human CTSB cDNA Clone(NM_147780.2) Inquiry
CDCS410512 Human CTSB ORF Clone (BC010240) Inquiry
CDCR318855 Human CTSB ORF Clone(NM_147782.2) Inquiry
CDCR318853 Human CTSB ORF Clone(NM_147781.2) Inquiry
CDCR318851 Human CTSB ORF Clone(NM_147780.2) Inquiry
CDCL183784 Human CTSB ORF clone(NM_001908.3) Inquiry
CDCB195442 Rabbit CTSB ORF clone (XM_002709436.2) Inquiry
CDCB167341 Chicken CTSB ORF Clone (NM_205371) Inquiry
CDCR379077 Rat Ctsb ORF Clone(NM_022597.2) Inquiry
CDCB157282 Mouse CTSB ORF clone (NM_007798.2) Inquiry
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